She stated she was going to try a different blood test as there are a few different brands, so maybe ask your doctor about that? Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Look up their websites and they will tell you the disorders they test for and the accuracy. So sorry to hear that! Stay off Google, oh my gosh, stay off Google! Why genetic testing is bad? (Don't quote me on that, just what I've read.). Why Genetic testing is bad? juliolovesme 2 yr. ago I'm so sorry to hear that! Thanks! Did you opt for an amnio? Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. We are repeating the assay on the same sample you have already sent and we should have that result on Wednesday. I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. I had my blood drawn for the NIPT test on 12/28. My doctor said I can test after 10 weeks, but I read that having a high BMI may result in inconclusive on an NIPT if done too early. Definitely something to bring up. Non-invasive prenatal testing (NIPT) using cell-free DNA in maternal blood is a relatively new screening modality for the common trisomies of chromosomes 21, 18 and 13 and sex chromosome aneuploidies. 1997-2023 BabyCenter, LLC, a Ziff Davis company. This time they are sending me to a high risk doctor. All rights reserved. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. Although I do have a very high BMI and am aware that this can cause inconclusive NIPT results too. Diagnostic fetal chromosome analysis should be offered after abnormal NIPT or in the presence of cystic hygromas despite normal NIPT. Please specify a reason for deleting this reply from the community. I'll do my 3rd test at nearly 16 weeks. So as others have said, keep the faith if your first test is inconclusive! I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. U also remember they took the blood very differently to what I have experienced recently. Noninvasive prenatal tests, or NIPTs, screen for an array of rare genetic conditions. You have all been so supportive, thank you so much. Repeated the test and no issues! I'm not sure how that works, but it doesn't necessarily indicate a problem. Ugh. My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. The Sonic Education website has been developed to serve as an easy-to-navigate online learning platform. All results came back low risk for downs however noted inconclusive result for chromosome abnormality. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). What Does NIPT Not Test For? If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Thank you for sharing your personal story with me. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. Not even gender. My fetal fraction on 2nd try was only 2.7% :( 3.8% sounds good! The cell-free DNA tests also screen for other chromosomal abnormalities other than Down's, such as Edward's syndrome. They are up to 99% accurate for chromosomal abnormalities. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. . I think in my case, my first test must have been borderline. Ugh. Also horrible stats about high incidence of redraw samples being inconclusive too. We went with Myriad. It's most likely the mosaicism, or a twin embryo that did not take. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. I just found out today at 12.5 weeks that my test was not conclusive. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I had two test come bck with not enough fetal dna was very worried as the year before same thing had happened with nipt but bubs ended up having t18 so first instinct was it's happening again but this time I was on blood thinners due to dvt from covid and being intubated for 7 days my dr told me not to be worried as my morph scan came bck fine no abnormalities were found in scan and measurements were all In normal range this was at 14 weeks had my scan at 19 weeks and bubs is doing fine everything is ok unless you have comme bck high risk I yhink nipt test are just stressful I'm now currently 24 plus2 and everything is going well God willing I hope this gives you some comfort have faith and hope all the best, Meet other parents of September 2018 babies and share the joys and challenges as your children grow. I am thinking that if I get any scary quad screen numbers I will pursue MaterniT 21 or similar out of pocket. Yes. We strive to provide you with a high quality community experience. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. Confirmed by amnio a week later. I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. They told me there wasn't enough fetal DNA in my blood to accurately complete the test. I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! To complete all the standard tests which came back fine and were able to identify that it was a boy but again, suspect maternal abmormality involving X chromosomes. I actually have an auto immune disease so they think thats why. But yes anyway, I'm sure it will all be fine. You're doing a great job, mama! When the test is repeated, about 1 in 3 repeat NIPT samples comes back with no result. All rights reserved. I'm wondering if because I'm a plus size mother? This educational content is not medical or diagnostic advice. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself. In cases where the father of the child has not been determined, couples may opt for a, Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. Just thought I'd update you or anyone else who may read this board. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. Has anyone else had this happen to them? Both said due to low fetal DNA at 2.6% and 2.7% respectively. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Id love to know emma went. No, NIPT is a screening test, not a diagnostic test. That means the results don't indicate for sure whether your baby has a chromosomal condition. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Here is a list of the most common questions we are asked. The #1 app for tracking pregnancy and baby growth. If there is insufficient fetal DNA. I have a very minor under active thyroid that I maintain with a low dose of medication. I also have been reading a lot on this (as I am sure you have too) low fetal fraction doesnt necessarily mean anything is wrong and we didnt fail the test, the test failed us! They have offered me a redraw. Please thank your mum for me. Easy to overthink (I sure did) and assume the worst - feels like Sod's law at the . The second test was done at 11 weeks. (1/19). Wouldn't that give you the results you're looking for? 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! Went back yesterday and did a redraw, and now I'm hoping this one takes. , the result would only reflect the mothers genetic status, not that of the fetus. Analysis of genes involved in drug metabolism and hypersensitivity, allowing clinicians to prescribe with confidence. If you click on the green no results tag low FF youll find all the posts about this in the sub. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. I had the same thing on my panorama test but I was 9 weeks. So i was referred to do nipt test. Happen to anyone ?? For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. Just got my 2nd no result today. Here are 3 factors that can lead to such a result. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Seems unfair to leave you in limbo not knowing. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. 20052023 BabyCenter, LLC, a Ziff Davis company. I'm so sorry to hear about your first trimester screening. Good luck! Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. This post is meant as a welcome and quick information / resources to those who have just found this sub. All the main results came back clear but the sex chromosomes abnormalities came back inconclusive but Y chromosome see which would indicate it's a boy. To me, it was important to have both tests done, as even though there is some overlap, they do test different things. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. NIPT Test Results Inconclusive! Were they able to get a conclusive result second time round? Anyone else have this come up? As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. the test and lead to no result. I really do feel for those that don't have as many affordable options. Fingers crossed for u! Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. The Sonic Genetics website includes general information regarding genetic testing, as well as specific information about particular tests. I wouldn't necessarily do the amnio for that if the baby is otherwise healthy. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. What company did your test? You can do an amnio. Costs about 50 bucks. It can come with its own set of risks. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. My NIPT came up inconclusive the first time as well. NIPT analyzes fragments of the baby's DNA found circulating in a pregnant person's blood. However, they got all the ones they needed for the NIPT which were good. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. harry hill family. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. All of your options are better than mine. So doesnt seem like Im low risk but My obgyn wants to refer me to see a geneticist to discuss possible next steps. ! Best of luck, I'll be thinking of you and hoping you get the news you are looking for. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Negative impact on family and personal relationships. This usually happens when a, Non-Invasive Prenatal Baby Gender Blood Test. So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. I'm not sure who it was but scroll back a bit and i'm sure you'll find it! I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. 2005-2023Everyday Health, Inc., a Ziff Davis company. Reasons behind an inconclusive prenatal paternity test. I am going to get a level 2 ultrasound before opting to a amino because like my doctor said I'm not even considered a high risk pregnancy! During pregnancy, opting for a non-invasive prenatal test has become the norm. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. However, the NT screens for things other than Down's. Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. Now I am in limbo awaiting to see what happens next. I had the test done and didn't have any issues with the results. There are many reasons NIPT may not give a result. Why should I choose Sonic to perform my NIPT? But I wish you all the best! The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. Luckily, my insurance covered both. Small bits of DNA are released from the placenta in to your blood. There are a few other reasons for odd results. *** Your email address will not be published. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Learn more about. Use of this site is subject to our terms of use and privacy policy. Anyone else experienced this? and mine came back at 3.7% and couldn't be read. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Identifying the genetic basis of familial disorders that affect children and adults. Or just monitor babies kidneys? The first rest was done around 10 weeks and the second around 14 weeks. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. Yes. NIPT (also called prenatal cell-free DNA screening) is a screening test that estimates the risk that your baby will be born with a genetic abnormality, including Down syndrome . I've read online it could happen to plus size moms? If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. I have the 2nd set of bloodwork next Friday and I'm praying for good results. sm1232, did you receive your results? I was worried too, so I did a bit of research on it. > This pageexplains some of these biological reasons. Normal chromosomes come. Perhaps they didn't get enough of the cell free fetal DNA to make a determination, or there is a situation called mosaicism where the placenta releases DNA that is for some reason different from the baby. In most cases, the results will say that a genetic condition is unlikely. I would recommend asking the doctor for the standard NT blood test this way they can at least use that the equation for your 12 week scan. Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. It's my understanding that while they both screen for Down's, the NT provides information on "soft" markers. Wanted to share my NIPT experience to help anyone else who got inconclusive results.I first took my NIPT test at 10 weeks on Sept. 30. I have a happy healthy 8 month old. Your post will be hidden and deleted by moderators. Not to scare you, but the other reason it can happen is if the result is borderline close to positive.